In the journal of his voyage to the Carolinas published in 1709, John Lawson connects the arrival of syphilis in America to Columbus, describing the striking consequences for the Santee,1 a Siouan population near the river of the same name in present-day South Carolina, which declined from about a thousand in the seventeenth century to less than ninety at the beginning of the eighteenth.2
On behalf of the Lords Proprietors of Carolina, to whom he dedicated his New Voyage, Lawson set out from Charleston on 28 December 1700, and arrived at the mouth of the Pamlico River (Pampticough) on 24 February 1701,3 drawing a wide arc in Carolina territories. It crossed and described an unmapped area, about which Europeans’ knowledge was largely lacking. The observer clearly identified the role of diseases of European origin, smallpox above all, in the rapid decline of populations such as the Sewee, another nation probably of Siouan stock, whose numbers, estimated at around eight hundred in the seventeenth century, were reduced to seventy-five in 1715:4
the Sewees have been formerly a large Nation, though now very much decreas’d since the English hath seated their Land, and all other Nations of Indians are observ’d to partake of the same Fate, where the Europeans come, the Indians being a People very apt to catch any Distemper they are afflicted withal; the Small-Pox has destroy’d many thousands of these Natives.
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